Next Generation Cancer-killing Genetic CAR-T Cell Therapeutics

Chi-Hoon Park, Ph. D.

  • Bio-organic Science Division, Pharmacology Research Center, Korea Research Institute of Chemical Technology, Daejeon, Korea
  • -Seoul National University, Seoul, Korea, B. S. in Chemistry March 1995 – February 1999.
    -Seoul National University, Seoul, Korea, M. S. in Biochemistry, March 1999 – February 2001.
    -Seoul National University, Seoul, Korea, Ph. D. in Biochemistry, March 2001 – August 2005.
  • -Post-Doctoral Scholar, Hillman Cancer Center, University of Pittsburgh Medical Center, USA
    -Post-Doctoral Scholar, National Cancer Institute, Bethesda, USA

Research

  • -Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC).
    -Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer.
    -Identification of novel ALK2 inhibitors and their effect on cancer cells.
    -Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells.
    -Mammalian Polo-like Kinase 1 (Plk1) Promotes Proper Chromosome Segregation by Phosphorylating and Delocalizing the PBIP1·CENP-Q Complex from Kinetochores.
    -Mammalian Polo-like Kinase 1-dependent Regulation of the PBIP1-Cenp-Q Complex at Kinetochores.
    -Fatty acids, inhibitors for the DNA binding of c-Myc/Max dimmer, suppress proliferation and induce apoptosis of differentiated HL-60 human leukemia cell.

Korea Research Institute of Chemical Technology

  • 141 Gajeong-ro, Jang-dong, Yuseong-gu, Daejeon, Republic of Korea
  • Korea Research Institute of Chemical Technology is a government-funded research institute established to develop source technologies and spread performance in chemical and related convergence technologies, and strengthening the competitiveness of the chemical industry through public infrastructure services.
  • The Korea Chemical Institute was established on September 2, 1976, following the Cabinet's vote on a plan to establish the Korea Chemical Institute. In 1980, the department in charge was changed from the Ministry of Commerce, Industry, and Energy to the Ministry of Science and Technology. In 1999, it was changed to the Ministry of Prime Minister's Office. The name was changed to the Korea Chemical Research Institute on January 1, 2001, and the department in charge was changed to the Ministry of Science and Technology in 2004, the Ministry of Knowledge Economy in 2008 and the Ministry of Science, and ICT and Future Planning in 2013.
  • It is focusing on developing source technologies in the chemical and related convergence sectors to strengthen the competitiveness of the chemical industry and creating new growth industries for the country. The research institute's vision has been set up as a research institute specializing in chemicals that realize a sustainable society, and key research areas include development of technologies for eco-friendly chemical processes, development of source technologies for high value-added green chemical materials, development of new materials pipelines and infrastructure technologies, development of technology for practical use of precision chemical and biomass-based materials, securing specialized technologies for chemical infrastructure and supporting comprehensive solutions.